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Ravi B. Upasani

Patent Agent

201-487-5800 phone

201-587-0715 fax

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RAVI B. UPASANI is a registered patent agent with broad experience in the pharmaceutical and chemical industries. Dr. Upasani received his Ph.D. in small molecule chemistry, and his qualifications include a unique combination of extensive experience in medicinal chemistry and expertise in Intellectual Property. Dr. Upasani has drafted over 200 patent applications and procured patents directed to inventions in a wide range of life science disciplines including pharmaceutical compositions of matter,, methods of treatment, pharmaceutical formulations, and manufacturing procedures for small molecules, peptides, peptoids, and polymers. In addition to preparation and prosecution of patent applications, Dr. Upasani is experienced in conducting freedom to operate (FTO) and patentability searches, chemical structure searches, and search analysis. Dr. Upasani was most recently the Senior Director of Intellectual Property at Pharmacyclics. Dr. Upasani also served as the Senior Director of IP at Renovis, Inc., and as the Director of IP and Business Development at Centaur Pharmaceuticals, Inc. His prior experience includes research in drug design, polymers, organo-magnetic materials, and super conducting materials. Dr. Upasani has authored more than 35 publications and is an inventor on more than 15 United States patents.

After completing his Ph.D., Ravi was awarded post-doctoral fellowships to continue his research at Rutgers University as well as Princeton University. His research at Rutgers was focused on designing and synthesizing novel GABAA receptor modulators.

Practice Areas

  • Structure based and SAR driven IP strategy, IP landscape analysis, pharmaceutical and chemical patent drafting, freedom to operate (FTO) and patentablity analysis, IP due diligence, Patent Life Cycle Management, and
    patent prosecution

Bar Admissions

  • Registered to practice before the U.S. Patent and Trademark Office

Education

  • Ph.D. in Small Molecule Chemistry, University of Bombay, 1984
  • M.Sc. in Small Molecule Chemistry, University of Bombay, 1981
  • B.Sc. in Chemistry, University of Bombay, 1977

Professional affiliations and memberships

    • American Chemical Society

Publications

Discovery of Subtype-Selective NMDA Receptor Ligands: 4-Benzyl-1-piperidinylalkynylpyrroles, Pyrazoles and Imidazoles as NR1A/2B Antagonist, J. L. Wright, P. A. Boxer, T. F. Gregory, S. Hong-Bae, J.-C. Huang, S. R. Kesten, L. T. Meltzer, R. B. Upasani, E. R. Whittemore, L. D. Wise, R. M. Woodward, K. C. Yang, and Z.-L. Zhou, Bioorg. Med. Chem. Lett. 1999, 9, 2815-2818

1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indoles: Potent subtype-selective inhibitors of N-Methyl-D-aspartate (NMDA) Receptors. A. P. Tamiz, E. R. Whittemore, R. M. Woodward, R. B. Upasani, J. F. W. Keana Bioorg. Med. Chem. Lett. 1999, 9, 1619-1624

Substituted 3-phenylethynyl derivatives of 3-hydroxy-5-pregnan-20-ones: remarkably potent neuroactive steroid modulators of the Gabaa receptors. Jon E. Hawkinson, Manuel Acosta-Burruel, Kevin C. Yang, Derk H. Hogenkamp, Nancy C. Lan, E. R. Whittemore, Richard M. Woodward, Richard B. Carter and Ravi B. Upasani*, J. Pharm. and Exp. Therap. 1998, 287, 198-207

-hydroxy--phenylethynyl-5-pregnan-20-ones: Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABAA receptors, R. B. Upasani, K. C. Yang, M. Acosta-Burruel, C. S. Konkoy, J. A. McLellan, R. M. Woodward, N. C. Lan, R. Carter, and J. E. Hawkinson, J. Med. Chem. 1997, 40, 73-84

Synthesis and in vitro activity of 3-substituted-3-hydroxypregnan-20-ones: Allosteric modulators of the GABAA receptor, D. Hogenkamp, S. H. Tahir, J. E. Hawkinson, R. Upasani, M. Alauddin, C. L. Kimbrough, M. Acosta-Burruel. E. R. Whittermore, R. M. Woodward, N. C. Lan, K. W. Gee, and M. B. Bolger, J. Med. Chem. 1997, 40, 61-72

Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593, S. Wieland, J. Bellushi, J. E. Hawkinson, D. Hogenkamp, R. Upasani, L. Stein, P. Wood, K. Gee, and N. C. Lan, Psychopharmacology 1997, 134, 46-54

In vitro and in vivo activity of 16,17-dehydro-epipregnanolones:17,20-bond torsional energy analysis and D-ring conformation, M. B. Bolger, S. Wieland, J. E. Hawkinson, H. Xia, R. B. Upasani and N. C. Lan Pharmaceutical Research, 1996, 13(10), 1486-92

Conformational similarity of diazepam-sensitive and -insensitive benzodiazepine receptors determined by chiral pyrroloimidazobenzodiazepines, R. I. Fryer, P. Zhang, K. Y. Lin R. B. Upasani, G. Wong, P. Skolnik, Med. Chem. Res. 1993, 3(3), 183-91

Studies related to alkylations of enolate anions of 1,4-benzodiazepinones R. I. Fryer, J. C. Pinto and R. B. Upasani J. Heterocycl. Chem. 1993, 30(4), 945-51

Patents
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same, U.S. PATENT 7,576,099

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same, U.S. PATENT 7,432,281

Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain, U.S. PATENT 7,115,666

Use of aryl nitrone compounds in methods for treating neuropathic pain, D. L. Waterbury, P. L. Wood, M. A. Khan, R. Upasani, U.S. PATENT 6,835,754

Neuroactive steroids of the androstane and pregnane series, Upasani et al., U.S. PATENT 6,780,853

Substituted quinazolines and analogs and the use thereof, R. Upasani, S. X. Cai, U.S. PATENT 6,765,006

Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof, P. Nguyen, D. J. Hogenkamp, R. B. Upasani, U.S. PATENT 6,737,418

Substituted quinazolines and analogs and use thereof, R. Upasani, S. X. Cai, N. Lan, Y. Wang, G. Field, D. B. Fick, U.S. PATENT 6,465,472

Aryl substituted pyrazoles and pyrroles, and the use thereof, D. J. Hogenkamp, R. B. Upasani, P. Nguyen, U.S. PATENT 6,414,011

Methods for allosteric modulation of the GABA receptor by members of the androstane and pregnane series (3-alkynyls), R. B. Upasani, H. J. Xia, D. J. Hogenkamp, U.S. PATENT 6,277,838

Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series (21-heterocycles and 3-phenylethynylpregnanes), R. B. Upasani, H. J. Xia, D. J. Hogenkamp, U.S. PATENT 6,143,736

4-Benzylpiperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists, J. L. Wright, R. B. Upasani, R. M. Woodward, N. C. Lan, U.S. PATENT 6,284,774

Methods, compositions, and compounds for Allosteric modulation of the GABA receptor by members of the androstane and pregane series (3-phenylethynylpregnanes), R. B. Upasani, H. J. Xia, D. J. Hogenkamp, U.S. PATENT 5,939,545

Neuroactive steroids of the androstane and pregane series (17-alkoxypregnanes), R. B. Upasani, D. J. Hogenkamp, D. B. Fick, N. C. Lan, U.S. PATENT 5,925,630

Process for synthesis of acetylenic carbinols, R. B. Upasani U.S. PATENT 5,567,830

Polysubstituted fullerenes and their preparation (C-2608), L. Y. Chiang, R. B. Upasani, and J. W. Swirczeski U.S. PATENT 5,416,188

Polysubstituted fullerenes and their preparation, L. Y. Chiang, R. B. Upasani, and J. W. Swirczeski U.S. PATENT 5,294,732

Formation of polysubstituted fullerenes, L. Y. Chiang, R. B. Upasani, and J. W. Swirczeski U.S. PATENT 5,177,248

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